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Automated HER2 Scoring in Breast Cancer Images Using Deep Learning and Pyramid Sampling
Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell growth that signifies the aggressiveness of breast cancer (BC) and helps predict its prognosis.
Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning
Systemic amyloidosis is a group of diseases characterized by the deposition of misfolded proteins in various organs and tissues, leading to progressive organ dysfunction and failure.
Multiplexed all-optical permutation operations using a reconfigurable diffractive optical network
We demonstrated the feasibility of this reconfigurable multiplexed diffractive design by approximating 256 randomly selected permutation matrices using K=4 rotatable diffractive layers.
Subwavelength Imaging using a Solid-Immersion Diffractive Optical Processor
To resolve subwavelength features of an object, the diffractive imager uses a thin, high-index solid-immersion layer to transmit high-frequency information of the object to a spatially-optimized diffractive encoder, which converts/encodes high-frequency information of the input into low-frequency spatial modes for transmission through air.
Complex-valued universal linear transformations and image encryption using spatially incoherent diffractive networks
Similarly, D2NNs can also perform arbitrary linear intensity transformations with spatially incoherent illumination; however, under spatially incoherent light, these transformations are non-negative, acting on diffraction-limited optical intensity patterns at the input field-of-view (FOV).
Pyramid diffractive optical networks for unidirectional magnification and demagnification
Our analyses revealed the efficacy of this P-D2NN design in unidirectional image magnification and demagnification tasks, producing high-fidelity magnified or demagnified images in only one direction, while inhibiting the image formation in the opposite direction - confirming the desired unidirectional imaging operation.
Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors
Under spatially-coherent light, a diffractive optical network composed of structured surfaces can be designed to perform any arbitrary complex-valued linear transformation between its input and output fields-of-view (FOVs) if the total number (N) of optimizable phase-only diffractive features is greater than or equal to ~2 Ni x No, where Ni and No refer to the number of useful pixels at the input and the output FOVs, respectively.
Data class-specific all-optical transformations and encryption
We numerically demonstrated all-optical class-specific transformations covering A-->A, I-->I, and P-->I transformations using various image datasets.
Deep Learning-enabled Virtual Histological Staining of Biological Samples
Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic assessment of tissue.
Virtual stain transfer in histology via cascaded deep neural networks
Unlike a single neural network structure which only takes one stain type as input to digitally output images of another stain type, C-DNN first uses virtual staining to transform autofluorescence microscopy images into H&E and then performs stain transfer from H&E to the domain of the other stain in a cascaded manner.
Few-shot Transfer Learning for Holographic Image Reconstruction using a Recurrent Neural Network
Here, we demonstrate a few-shot transfer learning method that helps a holographic image reconstruction deep neural network rapidly generalize to new types of samples using small datasets.
Holographic image reconstruction with phase recovery and autofocusing using recurrent neural networks
Digital holography is one of the most widely used label-free microscopy techniques in biomedical imaging.
Deep learning-based virtual refocusing of images using an engineered point-spread function
We present a virtual image refocusing method over an extended depth of field (DOF) enabled by cascaded neural networks and a double-helix point-spread function (DH-PSF).
