Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway

no code implementations • 17 Feb 2023 • Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga

In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus.

Drug Discovery

Three-component contour dynamics model to simulate and analyze amoeboid cell motility

no code implementations • 24 Oct 2022 • Daniel Schindler, Ted Moldenhawer, Carsten Beta, Wilhelm Huisinga, Matthias Holschneider

The model is used to generate contour data for a variety of qualitatively different, e. g., polarized and non-polarized, cell tracks that are hardly distinguishable from experimental data.

Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology

no code implementations • 1 Jun 2020 • Corinna Maier, Niklas Hartung, Charlotte Kloft, Wilhelm Huisinga, Jana de Wiljes

Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies.

reinforcement-learning Reinforcement Learning (RL)

Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows

no code implementations • 26 May 2020 • Daniel Schindler, Ted Moldenhawer, Maike Stange, Valentino Lepro, Carsten Beta, Matthias Holschneider, Wilhelm Huisinga

Amoeboid cell motility is essential for a wide range of biological processes including wound healing, embryonic morphogenesis, and cancer metastasis.