Deep manifold learning reveals hidden dynamics of proteasome autoregulation

1 code implementation • 23 Dec 2020 • Zhaolong Wu, Shuwen Zhang, Wei Li Wang, Yinping Ma, Yuanchen Dong, Youdong Mao

The 2. 5-MDa 26S proteasome maintains proteostasis and regulates myriad cellular processes.

3D Classification Clustering +1

A deep convolutional neural network approach to single-particle recognition in cryo-electron microscopy

no code implementations • 18 May 2016 • Yanan Zhu, Qi Ouyang, Youdong Mao

Conclusions: The DeepEM method derived from a deep CNN allows automated particle extraction from raw cryo-EM micrographs in the absence of templates, which demonstrated improved performance, objectivity and accuracy.

Unsupervised single-particle deep clustering via statistical manifold learning

no code implementations • 15 Apr 2016 • Jiayi Wu, Yong-Bei Ma, Charles Congdon, Bevin Brett, Shuobing Chen, Qi Ouyang, Youdong Mao

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination.

3D Reconstruction Clustering +2