An age-structured model of hepatitis B viral infection highlights the potential of different therapeutic strategies

no code implementations • 4 Aug 2021 • Farzad Fatehi, Richard J. Bingham, Eric C. Dykeman, Peter G. Stockley, Reidun Twarock

A comparison of different treatment options in the context of this model reveals that drugs targeting aspects of the viral life cycle are more effective than exhaustion therapy, a form of therapy mitigating immune response exhaustion.

Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study

no code implementations • 4 Aug 2021 • Farzad Fatehi, Richard J. Bingham, Pierre-Philippe Dechant, Peter G. Stockley, Reidun Twarock

Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome.