An interaction network approach predicts protein cage architectures in bionanotechnology

no code implementations • 26 Sep 2023 • Farzad Fatehi, Reidun Twarock

Protein nanoparticles play pivotal roles in many areas of bionanotechnology, including drug delivery, vaccination and diagnostics.

An age-structured model of hepatitis B viral infection highlights the potential of different therapeutic strategies

no code implementations • 4 Aug 2021 • Farzad Fatehi, Richard J. Bingham, Eric C. Dykeman, Peter G. Stockley, Reidun Twarock

A comparison of different treatment options in the context of this model reveals that drugs targeting aspects of the viral life cycle are more effective than exhaustion therapy, a form of therapy mitigating immune response exhaustion.

Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study

no code implementations • 4 Aug 2021 • Farzad Fatehi, Richard J. Bingham, Pierre-Philippe Dechant, Peter G. Stockley, Reidun Twarock

Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome.

Comparing antiviral strategies against COVID-19 via multiscale within-host modelling

no code implementations • 18 Oct 2020 • Farzad Fatehi, Richard J Bingham, Eric C Dykeman, Peter G Stockley, Reidun Twarock

Within-host models of COVID-19 infection dynamics enable the merits of different forms of antiviral therapy to be assessed in individual patients.