no code implementations • 1 Sep 2020 • Yue Wang, Renaud Dessalles, Tom Chou
We consider age-structured models with an imposed refractory period between births.
no code implementations • 18 Jun 2019 • Renaud Dessalles, Yunbei Pan, Mingtao Xia, Davide Maestrini, Maria R. D'Orsogna, Tom Chou
Using a mean-field approximation to the solution of a regulated birth-death-immigration model and a modification arising from sampling, we systematically quantify how TCR-dependent heterogeneities in immigration and proliferation rates affect the shape of clone abundance distributions (the number of different clones that are represented by a specific number of cells, or "clone counts").
no code implementations • 17 Nov 2017 • Renaud Dessalles, Vincent Fromion, Philippe Robert
In this article, we quantitatively study, through stochastic models, the efects of several intracellular phenomena, such as cell volume growth, cell division, gene replication as well as fuctuations of available RNA polymerases and ribosomes.