Search Results for author: Peter Neubauer

Found 9 papers, 0 papers with code

Data Augmentation Scheme for Raman Spectra with Highly Correlated Annotations

no code implementations1 Feb 2024 Christoph Lange, Isabel Thiele, Lara Santolin, Sebastian L. Riedel, Maxim Borisyak, Peter Neubauer, M. Nicolas Cruz Bournazou

This is of interest in scenarios where large amounts of historical data are available but are currently not used for model training.

Data Augmentation

Latent State Space Extension for interpretable hybrid mechanistic models

no code implementations6 Dec 2023 Judit Aizpuru, Maxim Borisyak, Peter Neubauer, M. Nicolas Cruz Bournazou

We demonstrate the framework's capabilities by fitting a hybrid model based on a simple mechanistic growth model for E. coli with data generated in-silico by a much more complex one and identifying missing kinetics.

Deep Set Neural Networks for forecasting asynchronous bioprocess timeseries

no code implementations4 Dec 2023 Maxim Borisyak, Stefan Born, Peter Neubauer, Mariano Nicolas Cruz-Bournazou

The method is agnostic to the particular nature of the time series and can be adapted for any task, for example, online monitoring, predictive control, design of experiments, etc.

Imputation Irregular Time Series +1

When Bioprocess Engineering Meets Machine Learning: A Survey from the Perspective of Automated Bioprocess Development

no code implementations2 Sep 2022 Nghia Duong-Trung, Stefan Born, Jong Woo Kim, Marie-Therese Schermeyer, Katharina Paulick, Maxim Borisyak, Mariano Nicolas Cruz-Bournazou, Thorben Werner, Randolf Scholz, Lars Schmidt-Thieme, Peter Neubauer, Ernesto Martinez

ML can be seen as a set of tools that contribute to the automation of the whole experimental cycle, including model building and practical planning, thus allowing human experts to focus on the more demanding and overarching cognitive tasks.

Model Selection Probabilistic Programming

Model predictive control and moving horizon estimation for adaptive optimal bolus feeding in high-throughput cultivation of \textit{E. coli}

no code implementations14 Mar 2022 Jong Woo Kim, Niels Krausch, Judit Aizpuru, Tilman Barz, Sergio Lucia, Peter Neubauer, Mariano Nicolas Cruz Bournazou

We discuss the application of a nonlinear model predictive control (MPC) and a moving horizon estimation (MHE) to achieve an optimal operation of \textit{E. coli} fed-batch cultivations with intermittent bolus feeding.

Model Predictive Control

Fitting nonlinear models to continuous oxygen data with oscillatory signal variations via a loss based on DynamicTime Warping

no code implementations25 Dec 2021 Judit Aizpuru, Annina Karolin Kemmer, Jong Woo Kim, Stefan Born, Peter Neubauer, Mariano N. Cruz Bournazou, Tilman Barz

TheDissolved Oxygen Tension is often the only measurement which is available online, and therefore, a good understanding of the errors in this signal is important for performing a robust estimation. Some of the expected errors will provoke uncertainties in the time-domain of the measurement, and in those cases, the common Weighted Least Squares estimation procedure can fail providing good results.

Dynamic Time Warping

Model predictive control guided with optimal experimental design for pulse-based parallel cultivation

no code implementations20 Dec 2021 Jong Woo Kim, Niels Krausch, Judit Aizpuru, Tilman Barz, Sergio Lucia, Ernesto C. Martínez, Peter Neubauer, Mariano Nicolas Cruz Bournazou

Optimal experimental design for parameter precision attempts to maximize the information content in experimental data for a most effective identification of parametric model.

Experimental Design Model Predictive Control

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