Modeling principles for a physiology-based whole-body model of human metabolism

no code implementations • 22 Apr 2024 • Laura Hjort Blicher, Peter Emil Carstensen, Jacob Bendsen, Henrik Linden, Bjørn Hald, Kim Kristensen, John Bagterp Jørgensen

Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important.

A whole-body mathematical model of cholesterol metabolism and transport

no code implementations • 22 Apr 2024 • Peter Emil Carstensen, Jacob Bendsen, Laura Hjort Blicher, Kim Kristensen, John Bagterp Jørgensen

A whole-body mathematical model for cholesterol metabolism and transport is proposed.

Management

Mathematical meal models for simulation of human metabolism

no code implementations • 31 Jul 2023 • Tobias K. S. Ritschel, Asbjørn Thode Reenberg, Peter Emil Carstensen, Jacob Bendsen, John Bagterp Jørgensen

We present and critically discuss five commonly used mathematical models of the meal glucose rate of appearance in humans.

Quantitative modeling and simulation of biochemical processes in the human body

no code implementations • 30 Jul 2023 • Jacob Bendsen, Peter Emil Carstensen, Asbjørn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp Jørgensen

We present a whole-body model of human metabolism that utilizes a system of organs and blood vessels to simulate the enzymatic reactions.

A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man

no code implementations • 3 May 2022 • Peter Emil Carstensen, Jacob Bendsen, Asbjørn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp Jørgensen

We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks.