no code implementations • 22 Apr 2024 • Peter Emil Carstensen, Jacob Bendsen, Laura Hjort Blicher, Kim Kristensen, John Bagterp Jørgensen
A whole-body mathematical model for cholesterol metabolism and transport is proposed.
no code implementations • 22 Apr 2024 • Laura Hjort Blicher, Peter Emil Carstensen, Jacob Bendsen, Henrik Linden, Bjørn Hald, Kim Kristensen, John Bagterp Jørgensen
Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important.
no code implementations • 19 Apr 2024 • Bruno Laurini, Nicola Cantisani, Wilson R. Leal da Silva, Yi Zong, John Bagterp Jørgensen
This article explores the electrification in clay calcination, proposing a dynamic model and energy management strategy for the integration of electrified calcination plants into sustainable power grids.
no code implementations • 14 Apr 2024 • Zhanhao Zhang, Jan Lorenz Svensen, Morten Wahlgreen Kaysfeld, Anders Hilmar Damm Christensen, Steen Hørsholt, John Bagterp Jørgensen
In the numerical experiment, we test and compare the proposed numerical methods.
no code implementations • 12 Apr 2024 • Zhanhao Zhang, Steen Hørsholt, John Bagterp Jørgensen
This paper presents the numerical discretization methods of the continuous-time linear-quadratic optimal control problems (LQ-OCPs) with time delays.
no code implementations • 11 Apr 2024 • Nicola Cantisani, Jan Lorenz Svensen, Ole Fink Hansen, John Bagterp Jørgensen
The model can be used, for example, to perform dynamic simulations with changing inputs, and process design and optimization.
no code implementations • 7 Feb 2024 • Anders Hilmar Damm Andersen, John Bagterp Jørgensen
This base case is an OCP that applies an ESDIRK method that refactorizes the iteration matrix in every Newton iteration and uses a direct approach for sensitivity computations.
no code implementations • 16 Nov 2023 • Nicola Cantisani, Josefine Dovits, John Bagterp Jørgensen
We develop a mathematical model for dynamical simulation of an alkaline electrolyzer plant.
no code implementations • 31 Jul 2023 • Tobias K. S. Ritschel, Asbjørn Thode Reenberg, Peter Emil Carstensen, Jacob Bendsen, John Bagterp Jørgensen
We present and critically discuss five commonly used mathematical models of the meal glucose rate of appearance in humans.
no code implementations • 30 Jul 2023 • Jacob Bendsen, Peter Emil Carstensen, Asbjørn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp Jørgensen
We present a whole-body model of human metabolism that utilizes a system of organs and blood vessels to simulate the enzymatic reactions.
no code implementations • 27 Feb 2023 • Anders H. D. Andersen, Zhanhao Zhang, Steen Hørsholt, Tobias K. S. Ritschel, John Bagterp Jørgensen
The key software principles are 1) shared data in the form of a database, files, or shared memory, 2) timers and threads for concurrent periodic execution of tasks, and 3) network communication between the control system and the process, and communication between the control system and the internet, e. g., the cloud to enable remote monitoring and commands.
no code implementations • 9 Dec 2022 • Anders H. D. Andersen, Tobias K. S. Ritschel, Steen Hørsholt, Jakob Kjøbsted Huusom, John Bagterp Jørgensen
We estimate the parameters in a continuous-discrete time stochastic nonlinear model for the QTS using a prediction-error-method based on the measured process data and a maximum likelihood (ML) criterion.
no code implementations • 5 Dec 2022 • Morten Ryberg Wahlgreen, John Bagterp Jørgensen, Mario Zanon
The PI tuning offers a wide range of tuning possibilities that is then inherited by the MPC design.
no code implementations • 5 Dec 2022 • Morten Wahlgreen Kaysfeld, Mario Zanon, John Bagterp Jørgensen
We perform high-performance Monte Carlo simulations in C enabled by a new thread-safe NMPC implementation in combination with an existing high-performance Monte Carlo simulation toolbox in C. We express the NMPC regulator as an optimal control problem (OCP), which we solve with the new thread-safe sequential quadratic programming software NLPSQP.
no code implementations • 25 Nov 2022 • Sarah Ellinor Engell, Tinna Björk Aradóttir, Tobias K. S. Ritschel, Henrik Bengtsson, John Bagterp Jørgensen
Specifically, we present a method to automatically estimate a personalized daily dose of basal insulin from closed-loop data collected with an AP.
no code implementations • 3 May 2022 • Peter Emil Carstensen, Jacob Bendsen, Asbjørn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp Jørgensen
We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks.