no code implementations • 23 Aug 2023 • Okyaz Eminaga, Mahmoud Abbas, Christian Kunder, Yuri Tolkach, Ryan Han, James D. Brooks, Rosalie Nolley, Axel Semjonow, Martin Boegemann, Robert West, Jin Long, Richard Fan, Olaf Bettendorf
Adjusting the decision threshold for the secondary Gleason pattern from 5% to 10% improved the concordance level between pathologists and vPatho for tumor grading on prostatectomy specimens (kappa from 0. 44 to 0. 64).
no code implementations • 29 Sep 2022 • Karin Stacke, Indrani Bhattacharya, Justin R. Tse, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu
CorrFABR consists of three main steps: (1) Feature Aggregation where region-level features are extracted from radiology and pathology images, (2) Fusion where radiology features correlated with pathology features are learned on a region level, and (3) Prediction where the learned correlated features are used to distinguish aggressive from indolent clear cell RCC using CT alone as input.
no code implementations • 3 Dec 2021 • Indrani Bhattacharya, David S. Lim, Han Lin Aung, Xingchen Liu, Arun Seetharaman, Christian A. Kunder, Wei Shao, Simon J. C. Soerensen, Richard E. Fan, Pejman Ghanouni, Katherine J. To'o, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu
Our experiments show that (1) radiologist labels and models trained with them can miss cancers, or underestimate cancer extent, (2) digital pathologist labels and models trained with them have high concordance with pathologist labels, and (3) models trained with digital pathologist labels achieve the best performance in prostate cancer detection in two different cohorts with different disease distributions, irrespective of the model architecture used.
no code implementations • 23 Jun 2021 • Wei Shao, Indrani Bhattacharya, Simon J. C. Soerensen, Christian A. Kunder, Jeffrey B. Wang, Richard E. Fan, Pejman Ghanouni, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu
Cancer labels achieved by image registration can be used to improve radiologists' interpretation of MRI by training deep learning models for early detection of prostate cancer.
1 code implementation • Medical Image Analysis 2021 • Rewa R. Sood, Wei Shao, Christian Kunder, Nikola C. Teslovich, Jeffrey B. Wang, Simon J.C. Soerensen, Nikhil Madhuripan, Anugayathri Jawahar, James D. Brooks, Pejman Ghanouni, Richard E. Fan, Geoffrey A. Sonn, Mirabela Rusu
Improvement in cancer detection on MRI is essential to reducing this variability and maximizing the clinical utility of MRI.
no code implementations • 31 Jul 2020 • Indrani Bhattacharya, Arun Seetharaman, Wei Shao, Rewa Sood, Christian A. Kunder, Richard E. Fan, Simon John Christoph Soerensen, Jeffrey B. Wang, Pejman Ghanouni, Nikola C. Teslovich, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu
First, the model learns MRI signatures of cancer that are correlated with corresponding histopathology features using Common Representation Learning.
no code implementations • 24 Aug 2019 • Okyaz Eminaga, Mahmoud Abbas, Christian Kunder, Andreas M. Loening, Jeanne Shen, James D. Brooks, Curtis P. Langlotz, Daniel L. Rubin
A well-fitted PlexusNet-based model delivered comparable classification performance (AUC: 0. 963) in distinguishing prostate cancer from healthy tissues, although it was at least 23 times smaller, had a better model calibration and clinical utility than the comparison models.
no code implementations • 17 Oct 2015 • Christopher J. Gatti, James D. Brooks, Sarah G. Nurre
We have developed a topic model, using Latent Dirichlet Allocation (LDA), and extend this analysis to reveal the temporal dynamics of the field, journals, and topics.