Search Results for author: James D. Brooks

Found 8 papers, 1 papers with code

Critical Evaluation of Artificial Intelligence as Digital Twin of Pathologist for Prostate Cancer Pathology

no code implementations23 Aug 2023 Okyaz Eminaga, Mahmoud Abbas, Christian Kunder, Yuri Tolkach, Ryan Han, James D. Brooks, Rosalie Nolley, Axel Semjonow, Martin Boegemann, Robert West, Jin Long, Richard Fan, Olaf Bettendorf

Adjusting the decision threshold for the secondary Gleason pattern from 5% to 10% improved the concordance level between pathologists and vPatho for tumor grading on prostatectomy specimens (kappa from 0. 44 to 0. 64).

Correlated Feature Aggregation by Region Helps Distinguish Aggressive from Indolent Clear Cell Renal Cell Carcinoma Subtypes on CT

no code implementations29 Sep 2022 Karin Stacke, Indrani Bhattacharya, Justin R. Tse, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu

CorrFABR consists of three main steps: (1) Feature Aggregation where region-level features are extracted from radiology and pathology images, (2) Fusion where radiology features correlated with pathology features are learned on a region level, and (3) Prediction where the learned correlated features are used to distinguish aggressive from indolent clear cell RCC using CT alone as input.

Binary Classification

Bridging the gap between prostate radiology and pathology through machine learning

no code implementations3 Dec 2021 Indrani Bhattacharya, David S. Lim, Han Lin Aung, Xingchen Liu, Arun Seetharaman, Christian A. Kunder, Wei Shao, Simon J. C. Soerensen, Richard E. Fan, Pejman Ghanouni, Katherine J. To'o, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu

Our experiments show that (1) radiologist labels and models trained with them can miss cancers, or underestimate cancer extent, (2) digital pathologist labels and models trained with them have high concordance with pathologist labels, and (3) models trained with digital pathologist labels achieve the best performance in prostate cancer detection in two different cohorts with different disease distributions, irrespective of the model architecture used.

BIG-bench Machine Learning

Weakly Supervised Registration of Prostate MRI and Histopathology Images

no code implementations23 Jun 2021 Wei Shao, Indrani Bhattacharya, Simon J. C. Soerensen, Christian A. Kunder, Jeffrey B. Wang, Richard E. Fan, Pejman Ghanouni, James D. Brooks, Geoffrey A. Sonn, Mirabela Rusu

Cancer labels achieved by image registration can be used to improve radiologists' interpretation of MRI by training deep learning models for early detection of prostate cancer.

Image Registration

Plexus Convolutional Neural Network (PlexusNet): A novel neural network architecture for histologic image analysis

no code implementations24 Aug 2019 Okyaz Eminaga, Mahmoud Abbas, Christian Kunder, Andreas M. Loening, Jeanne Shen, James D. Brooks, Curtis P. Langlotz, Daniel L. Rubin

A well-fitted PlexusNet-based model delivered comparable classification performance (AUC: 0. 963) in distinguishing prostate cancer from healthy tissues, although it was at least 23 times smaller, had a better model calibration and clinical utility than the comparison models.

General Classification

A Historical Analysis of the Field of OR/MS using Topic Models

no code implementations17 Oct 2015 Christopher J. Gatti, James D. Brooks, Sarah G. Nurre

We have developed a topic model, using Latent Dirichlet Allocation (LDA), and extend this analysis to reveal the temporal dynamics of the field, journals, and topics.

Management Specificity +1

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