Search Results for author: Ioan Gabriel Bucur

Found 7 papers, 6 papers with code

Inferring the Direction of a Causal Link and Estimating Its Effect via a Bayesian Mendelian Randomization Approach

1 code implementation18 Dec 2020 Ioan Gabriel Bucur, Tom Claassen, Tom Heskes

In this paper, we propose a Bayesian approach called BayesMR that is a generalization of the Mendelian randomization technique in which we allow for pleiotropic effects and, crucially, for the possibility of reverse causation.

MASSIVE: Tractable and Robust Bayesian Learning of Many-Dimensional Instrumental Variable Models

no code implementations18 Dec 2020 Ioan Gabriel Bucur, Tom Claassen, Tom Heskes

Unfortunately, searching for proper instruments in a many-dimensional set of candidates is a daunting task due to the intractable model space and the fact that we cannot directly test which of these candidates are valid, so most existing search methods either rely on overly stringent modeling assumptions or fail to capture the inherent model uncertainty in the selection process.

Causal Inference valid

Large-Scale Local Causal Inference of Gene Regulatory Relationships

1 code implementation3 Sep 2019 Ioan Gabriel Bucur, Tom Claassen, Tom Heskes

Many of these computational methods are designed to infer individual regulatory relationships among genes from data on gene expression.

Causal Inference

A Bayesian Approach for Inferring Local Causal Structure in Gene Regulatory Networks

1 code implementation18 Sep 2018 Ioan Gabriel Bucur, Tom van Bussel, Tom Claassen, Tom Heskes

Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data.

A Novel Bayesian Approach for Latent Variable Modeling from Mixed Data with Missing Values

2 code implementations12 Jun 2018 Ruifei Cui, Ioan Gabriel Bucur, Perry Groot, Tom Heskes

We consider the problem of learning parameters of latent variable models from mixed (continuous and ordinal) data with missing values.

Robust Causal Estimation in the Large-Sample Limit without Strict Faithfulness

1 code implementation6 Apr 2017 Ioan Gabriel Bucur, Tom Claassen, Tom Heskes

Causal effect estimation from observational data is an important and much studied research topic.

Causal Discovery

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