Pre-training Co-evolutionary Protein Representation via A Pairwise Masked Language Model

no code implementations • 29 Oct 2021 • Liang He, Shizhuo Zhang, Lijun Wu, Huanhuan Xia, Fusong Ju, He Zhang, Siyuan Liu, Yingce Xia, Jianwei Zhu, Pan Deng, Bin Shao, Tao Qin, Tie-Yan Liu

The key problem in the protein sequence representation learning is to capture the co-evolutionary information reflected by the inter-residue co-variation in the sequences.

Language Modelling Multiple Sequence Alignment +1