Evaluation of GPT-3 for Anti-Cancer Drug Sensitivity Prediction
In this study, we investigated the potential of GPT-3 for the anti-cancer drug sensitivity prediction task using structured pharmacogenomics data across five tissue types and evaluated its performance with zero-shot prompting and fine-tuning paradigms. The drug's smile representation and cell line's genomic mutation features were predictive of the drug response. The results from this study have the potential to pave the way for designing more efficient treatment protocols in precision oncology.
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Methods
Adam •
Attention Dropout •
BPE •
Cosine Annealing •
Dense Connections •
Dropout •
Fixed Factorized Attention •
GELU •
GPT-3 •
Layer Normalization •
Linear Layer •
Linear Warmup With Cosine Annealing •
Multi-Head Attention •
Residual Connection •
Scaled Dot-Product Attention •
Softmax •
Strided Attention •
Weight Decay
