Generating survival times using Cox proportional hazards models with cyclic time-varying covariates, with application to a multiple-dose monoclonal antibody clinical trial

1 code implementation • 25 Jan 2018 • Yunda Huang, Yuanyuan Zhang, Zong Zhang, Peter B. Gilbert

In two harmonized efficacy studies to prevent HIV infection through multiple infusions of the monoclonal antibody VRC01, a key objective is to evaluate whether the serum concentration of VRC01, which changes cyclically over time along with the infusion schedule, is associated with the rate of HIV infection.

Methodology