no code implementations • MICCAI Workshop COMPAY 2021 • Hanyun Zhang, Tami Grunewald, Ayse U. Akarca, Teresa Marafioti, Jonathan A. Ledermann, Yinyin Yuan
Deep-learning-based automatic analysis of the multiplex immunohistochemistry (mIHC) enables distinct cell populations to be localized on a large scale, providing insights into disease biology and therapeutic targets.
no code implementations • MICCAI Workshop COMPAY 2021 • Azam Hamidinekoo, Anna Kelsey, Nicholas Trahearn, Joanna Selfe, Janet Shipley, Yinyin Yuan
In order to be provided with a supportive micro-environment rich with resources to sustain optimal growth, tumour cells tend to reside in close proximity to a network of blood vessels.
1 code implementation • 23 Feb 2021 • Yeman Brhane Hagos, Catherine SY Lecat, Dominic Patel, Lydia Lee, Thien-An Tran, Manuel Rodriguez- Justo, Kwee Yong, Yinyin Yuan
To minimize the effect of cell imbalance on cell detection, we proposed a deep learning pipeline that considers the abundance of cell types during model training.
no code implementations • 10 Nov 2020 • Azam Hamidinekoo, Tomasz Pieciak, Maryam Afzali, Otar Akanyeti, Yinyin Yuan
The classification algorithm initially carries out tile-level (for histology) and slice-level (for radiology) classification via a deep learning method, then tile/slice-level latent features are combined for a whole-slide and whole-volume sub-type prediction.
no code implementations • 1 Aug 2019 • Yeman Brhane Hagos, Priya Lakshmi Narayanan, Ayse U. Akarca, Teresa Marafioti, Yinyin Yuan
Incorporating cell count loss in the objective function regularizes the network to learn weak gradient boundaries and separate weakly stained cells from background artefacts.
no code implementations • 7 Aug 2018 • Konstantinos Zormpas-Petridis, Henrik Failmezger, Ioannis Roxanis, Matthew Blackledge, Yann Jamin, Yinyin Yuan
The SLIC superpixel algorithm was used to segment and classify tumour regions in low resolution H&E-stained histological images of melanoma skin cancer to provide a global context.
no code implementations • 28 Jun 2018 • Priya Lakshmi Narayanan, Shan E Ahmed Raza, Andrew Dodson, Barry Gusterson, Mitchell Dowsett, Yinyin Yuan
Subsequently, seeds generated from cell segmentation were propagated to a spatially constrained convolutional neural network for the classification of the cells into stromal, lymphocyte, Ki67-positive cancer cell, and Ki67-negative cancer cell.
no code implementations • 18 Jun 2018 • Shan E Ahmed Raza, Khalid AbdulJabbar, Mariam Jamal-Hanjani, Selvaraju Veeriah, John Le Quesne, Charles Swanton, Yinyin Yuan
Output of the trained CNN is then deconvolved to generate points as cell detection.