1 code implementation • 23 Apr 2024 • Yang Tan, Mingchen Li, Bingxin Zhou, Bozitao Zhong, Lirong Zheng, Pan Tan, Ziyi Zhou, Huiqun Yu, Guisheng Fan, Liang Hong
Fine-tuning Pre-trained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches.
no code implementations • 3 Feb 2024 • Ziyi Zhou, Liang Zhang, Yuanxi Yu, Mingchen Li, Liang Hong, Pan Tan
Accurately modeling the protein fitness landscapes holds great importance for protein engineering.
1 code implementation • 26 Oct 2023 • Yang Tan, Mingchen Li, Pan Tan, Ziyi Zhou, Huiqun Yu, Guisheng Fan, Liang Hong
Moreover, despite the wealth of benchmarks and studies in the natural language community, there remains a lack of a comprehensive benchmark for systematically evaluating protein language model quality.
no code implementations • 24 Jul 2023 • Pan Tan, Mingchen Li, Yuanxi Yu, Fan Jiang, Lirong Zheng, Banghao Wu, Xinyu Sun, Liqi Kang, Jie Song, Liang Zhang, Yi Xiong, Wanli Ouyang, Zhiqiang Hu, Guisheng Fan, Yufeng Pei, Liang Hong
Designing protein mutants with high stability and activity is a critical yet challenging task in protein engineering.
no code implementations • 13 Apr 2023 • Bingxin Zhou, Outongyi Lv, Kai Yi, Xinye Xiong, Pan Tan, Liang Hong, Yu Guang Wang
Directed evolution as a widely-used engineering strategy faces obstacles in finding desired mutants from the massive size of candidate modifications.
no code implementations • 7 Apr 2023 • Pan Tan, Mingchen Li, Liang Zhang, Zhiqiang Hu, Liang Hong
We introduce TemPL, a novel deep learning approach for zero-shot prediction of protein stability and activity, harnessing temperature-guided language modeling.
no code implementations • 29 Dec 2022 • Mingchen Li, Liqi Kang, Yi Xiong, Yu Guang Wang, Guisheng Fan, Pan Tan, Liang Hong
Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism.
no code implementations • 5 Oct 2022 • Meng Sang, Jiaxuan Chen, Mengzhen Li, Pan Tan, Anning Pan, Shan Zhao, Yang Yang
In the field of face recognition, it is always a hot research topic to improve the loss solution to make the face features extracted by the network have greater discriminative power.