2 code implementations • Nature Machine Intelligence 2021 • Rui Qiao, Ngoc Hieu Tran, Lei Xin, Xin Chen, Ming Li, Baozhen Shan, Ali Ghodsi
De novo peptide sequencing is the key technology for finding novel peptides from mass spectra.
1 code implementation • 15 Sep 2020 • Fatema Tuz Zohora, M Ziaur Rahman, Ngoc Hieu Tran, Lei Xin, Baozhen Shan, Ming Li
A promising technique of discovering disease biomarkers is to measure the relative protein abundance in multiple biofluid samples through liquid chromatography with tandem mass spectrometry (LC-MS/MS) based quantitative proteomics.
1 code implementation • 17 Apr 2019 • Rui Qiao, Ngoc Hieu Tran, Lei Xin, Baozhen Shan, Ming Li, Ali Ghodsi
Personalized cancer vaccines are envisioned as the next generation rational cancer immunotherapy.
1 code implementation • Nature Methods 2018 • Ngoc Hieu Tran, Rui Qiao, Lei Xin, Xin Chen, Chuyi Liu, Xianglilan Zhang, Baozhen Shan, Ali Ghodsi, Ming Li
We present DeepNovo-DIA, a de novo peptide-sequencing method for data-independent acquisition (DIA) mass spectrometry data.
no code implementations • 9 Dec 2017 • Fatema Tuz Zohora, Ngoc Hieu Tran, Xianglilan Zhang, Lei Xin, Baozhen Shan, Ming Li
In this paper we propose a novel deep learning based model, DeepIso, that uses Convolutional Neural Networks (CNNs) to scan an LC-MS map to detect peptide features and estimate their abundance.
1 code implementation • 8 Oct 2017 • Ngoc Hieu Tran, Zachariah Levine, Lei Xin, Baozhen Shan, Ming Li
We combine two modules de novo sequencing and database search into a single deep learning framework for peptide identification, and integrate de Bruijn graph assembly technique to offer a complete solution to reconstruct protein sequences from tandem mass spectrometry data.
2 code implementations • PNAS 2017 • Ngoc Hieu Tran, Xianglilan Zhang, Lei Xin, Baozhen Shan, Ming Li
In this study, we propose a deep neural network model, DeepNovo, for de novo peptide sequencing.