Deep learning for reconstructing protein structures from cryo-EM density maps: recent advances and future directions

no code implementations • 16 Sep 2022 • Nabin Giri, Raj S. Roy, Jianlin Cheng

Cryo-Electron Microscopy (cryo-EM) has emerged as a key technology to determine the structure of proteins, particularly large protein complexes and assemblies in recent years.

DRLComplex: Reconstruction of protein quaternary structures using deep reinforcement learning

1 code implementation • 26 May 2022 • Elham Soltanikazemi, Raj S. Roy, Farhan Quadir, Nabin Giri, Alex Morehead, Jianlin Cheng

Utilizing true contacts as input, DRLComplex achieved high average TM-scores of 0. 9895 and 0. 9881 and a low average interface RMSD (I_RMSD) of 0. 2197 and 0. 92 on the two datasets, respectively.

reinforcement-learning Reinforcement Learning (RL) +1