no code implementations • 15 Sep 2023 • Marinka Zitnik, Michelle M. Li, Aydin Wells, Kimberly Glass, Deisy Morselli Gysi, Arjun Krishnan, T. M. Murali, Predrag Radivojac, Sushmita Roy, Anaïs Baudot, Serdar Bozdag, Danny Z. Chen, Lenore Cowen, Kapil Devkota, Anthony Gitter, Sara Gosline, Pengfei Gu, Pietro H. Guzzi, Heng Huang, Meng Jiang, Ziynet Nesibe Kesimoglu, Mehmet Koyuturk, Jian Ma, Alexander R. Pico, Nataša Pržulj, Teresa M. Przytycka, Benjamin J. Raphael, Anna Ritz, Roded Sharan, Yang shen, Mona Singh, Donna K. Slonim, Hanghang Tong, Xinan Holly Yang, Byung-Jun Yoon, Haiyuan Yu, Tijana Milenković
As such, it is expected to help shape short- and long-term vision for future computational and algorithmic research in network biology.
no code implementations • 17 Jan 2020 • Borislav H. Hristov, Bernard Chazelle, Mona Singh
Overall, our work suggests that guided network propagation approaches that utilize both prior and new data are a powerful means to identify disease genes.
no code implementations • 26 Apr 2017 • Borislav H. Hristov, Mona Singh
Here, we introduce a method that considers per-individual mutational profiles within the context of protein-protein interaction networks in order to identify small connected subnetworks of genes that, while not individually frequently mutated, comprise pathways that are perturbed across (i. e., "cover") a large fraction of the individuals.
3 code implementations • 23 Sep 2014 • Alejandro Ochoa, John D. Storey, Manuel Llinás, Mona Singh
E-values have been the dominant statistic for protein sequence analysis for the past two decades: from identifying statistically significant local sequence alignments to evaluating matches to hidden Markov models describing protein domain families.
Genomics