Search Results for author: Mona Singh

Found 4 papers, 1 papers with code

A guided network propagation approach to identify disease genes that combines prior and new information

no code implementations17 Jan 2020 Borislav H. Hristov, Bernard Chazelle, Mona Singh

Overall, our work suggests that guided network propagation approaches that utilize both prior and new data are a powerful means to identify disease genes.

Network-based coverage of mutational profiles reveals cancer genes

no code implementations26 Apr 2017 Borislav H. Hristov, Mona Singh

Here, we introduce a method that considers per-individual mutational profiles within the context of protein-protein interaction networks in order to identify small connected subnetworks of genes that, while not individually frequently mutated, comprise pathways that are perturbed across (i. e., "cover") a large fraction of the individuals.

Beyond the E-value: stratified statistics for protein domain prediction

3 code implementations23 Sep 2014 Alejandro Ochoa, John D. Storey, Manuel Llinás, Mona Singh

E-values have been the dominant statistic for protein sequence analysis for the past two decades: from identifying statistically significant local sequence alignments to evaluating matches to hidden Markov models describing protein domain families.

Genomics

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