no code implementations • 5 Jul 2020 • Li Xing, Songwan Joun, Kurt Mackay, Mary Lesperance, Xuekui Zhang
Method: We propose a grouping algorithm, which treats highly correlated genes as a group and uses their common pattern to represent the group's biological signal in feature selection.
no code implementations • 29 Jan 2019 • Li Xing, Mary Lesperance, Xuekui Zhang
Our goal is to build a model using data in this database, which simultaneously predicts the resistance of multiple drugs using mutation information from sequences of viruses for any new patient.
no code implementations • 7 May 2016 • Keelin Greenlaw, Elena Szefer, Jinko Graham, Mary Lesperance, Farouk S. Nathoo
Results: We develop a Bayesian hierarchical modeling formulation where the posterior mode corresponds to the estimator proposed by Wang et al. (Bioinformatics, 2012), and an approach that allows for full posterior inference including the construction of interval estimates for the regression parameters.
no code implementations • 27 Mar 2016 • Farouk S. Nathoo, Keelin Greenlaw, Mary Lesperance
We demonstrate these problems through simulation examples and study an approximation to the marginal likelihood which sheds light on the cause of this problem.