no code implementations • 19 Apr 2021 • Elisabeth G. Rens, Leah Edelstein-Keshet
The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge.
no code implementations • 21 Nov 2020 • Andreas Buttenschön, Leah Edelstein-Keshet
Mathematical and computational models can assist in gaining an understanding of cell behavior at many levels of organization.
no code implementations • 23 Sep 2019 • Yue Liu, Elisabeth G. Rens, Leah Edelstein-Keshet
The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases.
no code implementations • 28 Aug 2019 • Andreas Buttenschön, Yue Liu, Leah Edelstein-Keshet
We further consider the feedback between mechanical tension, GTPase activation, and cell deformation in both static, growing, shrinking, and moving cells.