no code implementations • 2 May 2024 • Nameyeh Alam, Jake Basilico, Daniele Bertolini, Satish Casie Chetty, Heather D'Angelo, Ryan Douglas, Charles K. Fisher, Franklin Fuller, Melissa Gomes, Rishabh Gupta, Alex Lang, Anton Loukianov, Rachel Mak-McCully, Cary Murray, Hanalei Pham, Susanna Qiao, Elena Ryapolova-Webb, Aaron Smith, Dimitri Theoharatos, Anil Tolwani, Eric W. Tramel, Anna Vidovszky, Judy Viduya, Jonathan R. Walsh
We show that the same neural network architecture can be trained to generate accurate digital twins for patients across 13 different indications simply by changing the training set and tuning hyperparameters.
no code implementations • 29 Feb 2024 • Yunfan Li, Arman Sabbaghi, Jonathan R. Walsh, Charles K. Fisher
We demonstrate that prognostic score adjustment in logistic regression increases the power of the Wald test for the conditional odds ratio under a fixed sample size, or alternatively reduces the necessary sample size to achieve a desired power, compared to the unadjusted analysis.
no code implementations • 25 Sep 2023 • Alyssa M. Vanderbeek, Anna A. Vidovszky, Jessica L. Ross, Arman Sabbaghi, Jonathan R. Walsh, Charles K. Fisher, the Critical Path for Alzheimer's Disease, the Alzheimer's Disease Neuroimaging Initiative, the European Prevention of Alzheimer's Disease, Consortium, the Alzheimer's Disease Cooperative Study
A crucial task for a randomized controlled trial (RCT) is to specify a statistical method that can yield an efficient estimator and powerful test for the treatment effect.
no code implementations • 24 Dec 2020 • Daniele Bertolini, Anton D. Loukianov, Aaron M. Smith, David Li-Bland, Yannick Pouliot, Jonathan R. Walsh, Charles K. Fisher
Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments.
no code implementations • 4 Feb 2020 • Jonathan R. Walsh, Aaron M. Smith, Yannick Pouliot, David Li-Bland, Anton Loukianov, Charles K. Fisher
Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments.
no code implementations • 10 Jul 2018 • Charles K. Fisher, Aaron M. Smith, Jonathan R. Walsh, the Coalition Against Major Diseases
Most approaches to machine learning from electronic health data can only predict a single endpoint.
1 code implementation • 23 Apr 2018 • Charles K. Fisher, Aaron M. Smith, Jonathan R. Walsh
Restricted Boltzmann Machines (RBMs) are a class of generative neural network that are typically trained to maximize a log-likelihood objective function.