A biophysical network model reveals the link between deficient inhibitory cognitive control and major neurotransmitter and neural connectivity hypotheses in schizophrenia

no code implementations • 20 Jul 2021 • Konstantinos Spiliotis, Giannis Kahramanoglou, Jens Starke, Nikolaos Smyrnis, Constantinos Siettos

We address a biophysical network dynamical model to study how the modulation of dopamine (DA) activity and related N-methyl-d-aspartate (NMDA) glutamate receptor activity as well as the emerging Pre-Frontal Cortex (PFC) functional connectivity network (FCN) affect inhibitory cognitive function in schizophrenia in an antisaccade task.

Deep brain stimulation for movement disorder treatment: Exploring frequency-dependent efficacy in a computational network model

no code implementations • 14 Oct 2020 • Konstantinos Spiliotis, Jens Starke, Denise Franz, Angelika Richter, Rüdiger Köhling

It can be demonstrated that depending on different levels of striatal projections to the GPe and GPi, the dynamics of these macroscopic quantities switch from normal conditions to parkinsonian.