Search Results for author: Jeffrey Ruffolo

Found 2 papers, 2 papers with code

Towards Joint Sequence-Structure Generation of Nucleic Acid and Protein Complexes with SE(3)-Discrete Diffusion

1 code implementation21 Dec 2023 Alex Morehead, Jeffrey Ruffolo, Aadyot Bhatnagar, Ali Madani

In this work, we introduce MMDiff, a generative model that jointly designs sequences and structures of nucleic acid and protein complexes, independently or in complex, using joint SE(3)-discrete diffusion noise.

ProGen2: Exploring the Boundaries of Protein Language Models

4 code implementations27 Jun 2022 Erik Nijkamp, Jeffrey Ruffolo, Eli N. Weinstein, Nikhil Naik, Ali Madani

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design.

Protein Design

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