Plug & Play Directed Evolution of Proteins with Gradient-based Discrete MCMC

1 code implementation • 20 Dec 2022 • Patrick Emami, Aidan Perreault, Jeffrey Law, David Biagioni, Peter C. St. John

We introduce a sampling framework for evolving proteins in silico that supports mixing and matching a variety of unsupervised models, such as protein language models, and supervised models that predict protein function from sequence.

Protein Language Model