What cleaves? Is proteasomal cleavage prediction reaching a ceiling?

1 code implementation • 24 Oct 2022 • Ingo Ziegler, Bolei Ma, Ercong Nie, Bernd Bischl, David Rügamer, Benjamin Schubert, Emilio Dorigatti

While direct identification of proteasomal cleavage \emph{in vitro} is cumbersome and low throughput, it is possible to implicitly infer cleavage events from the termini of MHC-presented epitopes, which can be detected in large amounts thanks to recent advances in high-throughput MHC ligandomics.

Benchmarking Denoising