Search Results for author: Hon-Cheong So

Found 3 papers, 3 papers with code

SumVg: Total heritability explained by all variants in genome-wide association studies based on summary statistics with standard error estimates

1 code implementation • 25 Jun 2023 • Hon-Cheong So, Xiao Xue, Pak-Chung Sham

In this study we developed several resampling-based approaches to estimate the SE of SNP-based heritability, including two jackknife and three parametric bootstrap methods.

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A framework to decipher the genetic architecture of combinations of complex diseases: applications in cardiovascular medicine

1 code implementation • 19 Mar 2020 • Liangying Yin, Carlos Kwan-long Chau, Yu-Ping Lin, Pak-Chung Sham, Hon-Cheong So

In essence, we mimicked a case-control GWAS in which the cases are affected with comorbidities or a disease without a relevant comorbid condition (in either case, we may consider the cases as those affected by a specific subtype of disease, as characterized by the presence or absence of comorbid conditions).

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Analysis of genetic differences between psychiatric disorders: Exploring pathways and cell-types/tissues involved and ability to differentiate the disorders by polygenic scores

1 code implementation • 16 Mar 2020 • Shitao Rao, Liangying Yin, Yong Xiang, Hon-Cheong So

Based on current GWAS data, PRS have mostly modest power to distinguish between psychiatric disorders.

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