no code implementations • 13 Oct 2022 • Axel Levy, Gordon Wetzstein, Julien Martel, Frederic Poitevin, Ellen D. Zhong
Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life.
no code implementations • 3 Jul 2021 • Ellen D. Zhong, Adam Lerer, Joseph H. Davis, Bonnie Berger
Although reconstruction algorithms typically model the 3D volume as a generic function parameterized as a voxel array or neural network, the underlying atomic structure of the protein of interest places well-defined physical constraints on the reconstructed structure.
no code implementations • ICCV 2021 • Ellen D. Zhong, Adam Lerer, Joseph H. Davis, Bonnie Berger
In this work we describe cryoDRGN2, an ab initio reconstruction algorithm, which can jointly estimate image poses and learn a neural model of a distribution of 3D structures on real heterogeneous cryo-EM data.
1 code implementation • NeurIPS 2019 • Tristan Bepler, Ellen D. Zhong, Kotaro Kelley, Edward Brignole, Bonnie Berger
Given an image dataset, we are often interested in finding data generative factors that encode semantic content independently from pose variables such as rotation and translation.
2 code implementations • ICLR 2020 • Ellen D. Zhong, Tristan Bepler, Joseph H. Davis, Bonnie Berger
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution.