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Found 3 papers, 3 papers with code
Inference of B cell clonal families using heavy/light chain pairing information
Next generation sequencing of B cell receptor (BCR) repertoires has become a ubiquitous tool for understanding the antibody-mediated immune response: it is now common to have large volumes of sequence data coding for both the heavy and light chain subunits of the BCR.
Using B cell receptor lineage structures to predict affinity
In this paper we introduce a method that uses evolutionary information from the family of related sequences that share a naive ancestor to predict the affinity of each resulting antibody for its antigen.
A Bayesian Phylogenetic Hidden Markov Model for B Cell Receptor Sequence Analysis
Statistical phylogenetic methods are often used to model the mutational dynamics of BCR sequence data, but these techniques do not consider all the complexities associated with B cell diversification such as the V(D)J rearrangement process.
Methodology Genomics Applications
