no code implementations • 25 Sep 2023 • Alex G. C. de Sá, Daniel Gould, Anna Fedyukova, Mitchell Nicholas, Lucy Dockrell, Calvin Fletcher, David Pilcher, Daniel Capurro, David B. Ascher, Khaled El-Khawas, Douglas E. V. Pires
Readmission contributes to this pathway's difficulty, occurring when patients are admitted again to the ICU in a short timeframe, resulting in high mortality rates and high resource utilisation.
no code implementations • 3 Sep 2023 • Bruna Moreira da Silva, David B. Ascher, Nicholas Geard, Douglas E. V. Pires
Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens.
no code implementations • 9 Jul 2021 • Gyorgy Abrusan, David B. Ascher, Michael Inouye
We show that 1) known allosteric proteins are central in disease networks, and contribute to genetic disease and comorbidities much more than non-allosteric proteins, in many major disease types like hematopoietic diseases, cardiovascular diseases, cancers, diabetes, or diseases of the central nervous system.