Uncertainty-inspired Open Set Learning for Retinal Anomaly Identification

8 Apr 2023 · Meng Wang, Tian Lin, Lianyu Wang, Aidi Lin, Ke Zou, Xinxing Xu, Yi Zhou, Yuanyuan Peng, Qingquan Meng, Yiming Qian, Guoyao Deng, Zhiqun Wu, Junhong Chen, Jianhong Lin, Mingzhi Zhang, Weifang Zhu, Changqing Zhang, Daoqiang Zhang, Rick Siow Mong Goh, Yong liu, Chi Pui Pang, Xinjian Chen, Haoyu Chen, Huazhu Fu ·

Failure to recognize samples from the classes unseen during training is a major limitation of artificial intelligence in the real-world implementation for recognition and classification of retinal anomalies. We established an uncertainty-inspired open-set (UIOS) model, which was trained with fundus images of 9 retinal conditions. Besides assessing the probability of each category, UIOS also calculated an uncertainty score to express its confidence. Our UIOS model with thresholding strategy achieved an F1 score of 99.55%, 97.01% and 91.91% for the internal testing set, external target categories (TC)-JSIEC dataset and TC-unseen testing set, respectively, compared to the F1 score of 92.20%, 80.69% and 64.74% by the standard AI model. Furthermore, UIOS correctly predicted high uncertainty scores, which would prompt the need for a manual check in the datasets of non-target categories retinal diseases, low-quality fundus images, and non-fundus images. UIOS provides a robust method for real-world screening of retinal anomalies.

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