The Deception Detection and Physiological Monitoring (DDPM) dataset captures an interview scenario in which the interviewee attempts to deceive the interviewer on selected responses. The interviewee is recorded in RGB, near-infrared, and long-wave infrared, along with cardiac pulse, blood oxygenation, and audio. After collection, data were annotated for interviewer/interviewee, curated, ground-truthed, and organized into train/test parts for a set of canonical deception detection experiments. The dataset contains almost 13 hours of recordings of 70 subjects, and over 8 million visible-light, near-infrared, and thermal video frames, along with appropriate meta, audio, and pulse oximeter data.