no code implementations • 26 Apr 2017 • Tejal Bhamre, Teng Zhang, Amit Singer
The missing phase problem in X-ray crystallography is commonly solved using the technique of molecular replacement, which borrows phases from a previously solved homologous structure, and appends them to the measured Fourier magnitudes of the diffraction patterns of the unknown structure.
no code implementations • 10 Nov 2016 • Tejal Bhamre, Zhizhen Zhao, Amit Singer
Single particle reconstruction (SPR) from cryo-electron microscopy (EM) is a technique in which the 3D structure of a molecule needs to be determined from its contrast transfer function (CTF) affected, noisy 2D projection images taken at unknown viewing directions.
no code implementations • 22 Feb 2016 • Tejal Bhamre, Teng Zhang, Amit Singer
In CWF, the covariance matrix of the projection images is used within the classical Wiener filtering framework for solving the image restoration deconvolution problem.
no code implementations • 1 Dec 2014 • Tejal Bhamre, Teng Zhang, Amit Singer
In single particle reconstruction (SPR) from cryo-electron microscopy (cryo-EM), the 3D structure of a molecule needs to be determined from its 2D projection images taken at unknown viewing directions.