Search Results for author: Parashkev Nachev

Found 43 papers, 16 papers with code

RAISE -- Radiology AI Safety, an End-to-end lifecycle approach

no code implementations24 Nov 2023 M. Jorge Cardoso, Julia Moosbauer, Tessa S. Cook, B. Selnur Erdal, Brad Genereaux, Vikash Gupta, Bennett A. Landman, Tiarna Lee, Parashkev Nachev, Elanchezhian Somasundaram, Ronald M. Summers, Khaled Younis, Sebastien Ourselin, Franz MJ Pfister

The integration of AI into radiology introduces opportunities for improved clinical care provision and efficiency but it demands a meticulous approach to mitigate potential risks as with any other new technology.

Fairness Scheduling

Compressed representation of brain genetic transcription

no code implementations24 Oct 2023 James K Ruffle, Henry Watkins, Robert J Gray, Harpreet Hyare, Michel Thiebaut de Schotten, Parashkev Nachev

The architecture of the brain is too complex to be intuitively surveyable without the use of compressed representations that project its variation into a compact, navigable space.

Computational limits to the legibility of the imaged human brain

1 code implementation23 Aug 2023 James K Ruffle, Robert J Gray, Samia Mohinta, Guilherme Pombo, Chaitanya Kaul, Harpreet Hyare, Geraint Rees, Parashkev Nachev

It remains unknown whether the difficulty arises from the absence of individuating biological patterns within the brain, or from limited power to access them with the models and compute at our disposal.

Generative AI for Medical Imaging: extending the MONAI Framework

2 code implementations27 Jul 2023 Walter H. L. Pinaya, Mark S. Graham, Eric Kerfoot, Petru-Daniel Tudosiu, Jessica Dafflon, Virginia Fernandez, Pedro Sanchez, Julia Wolleb, Pedro F. da Costa, Ashay Patel, Hyungjin Chung, Can Zhao, Wei Peng, Zelong Liu, Xueyan Mei, Oeslle Lucena, Jong Chul Ye, Sotirios A. Tsaftaris, Prerna Dogra, Andrew Feng, Marc Modat, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

We have implemented these models in a generalisable fashion, illustrating that their results can be extended to 2D or 3D scenarios, including medical images with different modalities (like CT, MRI, and X-Ray data) and from different anatomical areas.

Anomaly Detection Denoising +2

Patch-CNN: Training data-efficient deep learning for high-fidelity diffusion tensor estimation from minimal diffusion protocols

no code implementations3 Jul 2023 Tobias Goodwin-Allcock, Ting Gong, Robert Gray, Parashkev Nachev, HUI ZHANG

To overcome these limitations, we propose Patch-CNN, a neural network with a minimal (non-voxel-wise) convolutional kernel (3$\times$3$\times$3).

Deep Variational Lesion-Deficit Mapping

1 code implementation27 May 2023 Guilherme Pombo, Robert Gray, Amy P. K. Nelson, Chris Foulon, John Ashburner, Parashkev Nachev

Here we initiate the application of deep generative neural network architectures to the task of lesion-deficit inference, formulating it as the estimation of an expressive hierarchical model of the joint lesion and deficit distributions conditioned on a latent neural substrate.

Brain tumour genetic network signatures of survival

no code implementations15 Jan 2023 James K Ruffle, Samia Mohinta, Guilherme Pombo, Robert Gray, Valeriya Kopanitsa, Faith Lee, Sebastian Brandner, Harpreet Hyare, Parashkev Nachev

Tumour heterogeneity is increasingly recognized as a major obstacle to therapeutic success across neuro-oncology.

Denoising diffusion models for out-of-distribution detection

1 code implementation14 Nov 2022 Mark S. Graham, Walter H. L. Pinaya, Petru-Daniel Tudosiu, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

We propose to use DDPMs to reconstruct an input that has been noised to a range of noise levels, and use the resulting multi-dimensional reconstruction error to classify out-of-distribution inputs.

Denoising Out-of-Distribution Detection

Focal and Connectomic Mapping of Transiently Disrupted Brain Function

no code implementations1 Nov 2022 Michael S. Elmalem, Hanna Moody, James K. Ruffle, Michel Thiebaut de Schotten, Patrick Haggard, Beate Diehl, Parashkev Nachev, Ashwani Jha

Our framework enables disruptive mapping of the human brain based on sparsely sampled data with minimal spatial assumptions, good statistical efficiency, flexible model formulation, and explicit comparison of local and distributed effects.

Brain Imaging Generation with Latent Diffusion Models

1 code implementation15 Sep 2022 Walter H. L. Pinaya, Petru-Daniel Tudosiu, Jessica Dafflon, Pedro F Da Costa, Virginia Fernandez, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

In this study, we explore using Latent Diffusion Models to generate synthetic images from high-resolution 3D brain images.

Morphology-preserving Autoregressive 3D Generative Modelling of the Brain

1 code implementation7 Sep 2022 Petru-Daniel Tudosiu, Walter Hugo Lopez Pinaya, Mark S. Graham, Pedro Borges, Virginia Fernandez, Dai Yang, Jeremy Appleyard, Guido Novati, Disha Mehra, Mike Vella, Parashkev Nachev, Sebastien Ourselin, Jorge Cardoso

Still, the ability to produce high-resolution 3D volumetric imaging data with correct anatomical morphology has been hampered by data scarcity and algorithmic and computational limitations.

Anatomy Anomaly Detection

How can spherical CNNs benefit ML-based diffusion MRI parameter estimation?

no code implementations1 Jul 2022 Tobias Goodwin-Allcock, Jason McEwen, Robert Gray, Parashkev Nachev, HUI ZHANG

A possible consequence of the lack of rotational equivariance is that the training dataset must contain a diverse range of microstucture orientations.

Brain tumour segmentation with incomplete imaging data

no code implementations13 Jun 2022 James K Ruffle, Samia Mohinta, Robert J Gray, Harpreet Hyare, Parashkev Nachev

This is a task contemporary machine learning could facilitate, especially in neuroimaging, but its ability to deal with incomplete data common in real world clinical practice remains unknown.

Segmentation

Equitable modelling of brain imaging by counterfactual augmentation with morphologically constrained 3D deep generative models

no code implementations29 Nov 2021 Guilherme Pombo, Robert Gray, Jorge Cardoso, Sebastien Ourselin, Geraint Rees, John Ashburner, Parashkev Nachev

The model is intended to synthesise counterfactual training data augmentations for downstream discriminative modelling tasks where fidelity is limited by data imbalance, distributional instability, confounding, or underspecification, and exhibits inequitable performance across distinct subpopulations.

counterfactual

Value-aware transformers for 1.5d data

no code implementations29 Sep 2021 James F Cann, Timothy J Roberts, Amy R Tso, Amy Nelson, Parashkev Nachev

Sparse sequential highly-multivariate data of the form characteristic of hospital in-patient investigation and treatment poses a considerable challenge for representation learning.

Length-of-Stay prediction Representation Learning

An MRF-UNet Product of Experts for Image Segmentation

1 code implementation12 Apr 2021 Mikael Brudfors, Yaël Balbastre, John Ashburner, Geraint Rees, Parashkev Nachev, Sébastien Ourselin, M. Jorge Cardoso

While convolutional neural networks (CNNs) trained by back-propagation have seen unprecedented success at semantic segmentation tasks, they are known to struggle on out-of-distribution data.

Image Segmentation Semantic Segmentation

Unsupervised Brain Anomaly Detection and Segmentation with Transformers

no code implementations23 Feb 2021 Walter Hugo Lopez Pinaya, Petru-Daniel Tudosiu, Robert Gray, Geraint Rees, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

Pathological brain appearances may be so heterogeneous as to be intelligible only as anomalies, defined by their deviation from normality rather than any specific pathological characteristic.

Unsupervised Anomaly Detection

Generative Model-Enhanced Human Motion Prediction

2 code implementations5 Oct 2020 Anthony Bourached, Ryan-Rhys Griffiths, Robert Gray, Ashwani Jha, Parashkev Nachev

The task of predicting human motion is complicated by the natural heterogeneity and compositionality of actions, necessitating robustness to distributional shifts as far as out-of-distribution (OoD).

Human motion prediction motion prediction

Test-time Unsupervised Domain Adaptation

no code implementations5 Oct 2020 Thomas Varsavsky, Mauricio Orbes-Arteaga, Carole H. Sudre, Mark S. Graham, Parashkev Nachev, M. Jorge Cardoso

Convolutional neural networks trained on publicly available medical imaging datasets (source domain) rarely generalise to different scanners or acquisition protocols (target domain).

Unsupervised Domain Adaptation

Hierarchical brain parcellation with uncertainty

no code implementations16 Sep 2020 Mark S. Graham, Carole H. Sudre, Thomas Varsavsky, Petru-Daniel Tudosiu, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

We introduce a hierarchically-aware brain parcellation method that works by predicting the decisions at each branch in the label tree.

Flexible Bayesian Modelling for Nonlinear Image Registration

no code implementations3 Jun 2020 Mikael Brudfors, Yaël Balbastre, Guillaume Flandin, Parashkev Nachev, John Ashburner

We describe a diffeomorphic registration algorithm that allows groups of images to be accurately aligned to a common space, which we intend to incorporate into the SPM software.

Anatomy Image Registration

Neuromorphologicaly-preserving Volumetric data encoding using VQ-VAE

no code implementations MIDL 2019 Petru-Daniel Tudosiu, Thomas Varsavsky, Richard Shaw, Mark Graham, Parashkev Nachev, Sebastien Ourselin, Carole H. Sudre, M. Jorge Cardoso

The increasing efficiency and compactness of deep learning architectures, together with hardware improvements, have enabled the complex and high-dimensional modelling of medical volumetric data at higher resolutions.

Unsupervised Videographic Analysis of Rodent Behaviour

no code implementations22 Oct 2019 Anthony Bourached, Parashkev Nachev

Animal behaviour is complex and the amount of data in the form of video, if extracted, is copious.

A Tool for Super-Resolving Multimodal Clinical MRI

2 code implementations3 Sep 2019 Mikael Brudfors, Yael Balbastre, Parashkev Nachev, John Ashburner

The model-driven nature of the approach means that no type of training is needed for applicability to the diversity of MR contrasts present in a clinical context.

Multi-Domain Adaptation in Brain MRI through Paired Consistency and Adversarial Learning

no code implementations16 Aug 2019 Mauricio Orbes-Arteaga, Thomas Varsavsky, Carole H. Sudre, Zach Eaton-Rosen, Lewis J. Haddow, Lauge Sørensen, Mads Nielsen, Akshay Pai, Sébastien Ourselin, Marc Modat, Parashkev Nachev, M. Jorge Cardoso

Inspired by recent work in semi-supervised learning we introduce a novel method to adapt from one source domain to $n$ target domains (as long as there is paired data covering all domains).

Domain Adaptation

Empirical Bayesian Mixture Models for Medical Image Translation

no code implementations16 Aug 2019 Mikael Brudfors, John Ashburner, Parashkev Nachev, Yael Balbastre

Automatically generating one medical imaging modality from another is known as medical image translation, and has numerous interesting applications.

Translation

Bayesian Volumetric Autoregressive generative models for better semisupervised learning

1 code implementation26 Jul 2019 Guilherme Pombo, Robert Gray, Tom Varsavsky, John Ashburner, Parashkev Nachev

Second, we show that reformulating this model to approximate a deep Gaussian process yields a measure of uncertainty that improves the performance of semi-supervised learning, in particular classification performance in settings where the proportion of labelled data is low.

General Classification Semantic Segmentation

MRI Super-Resolution using Multi-Channel Total Variation

4 code implementations8 Oct 2018 Mikael Brudfors, Yael Balbastre, Parashkev Nachev, John Ashburner

This paper presents a generative model for super-resolution in routine clinical magnetic resonance images (MRI), of arbitrary orientation and contrast.

Brain Segmentation Super-Resolution

Elastic Registration of Geodesic Vascular Graphs

no code implementations14 Sep 2018 Stefano Moriconi, Maria A. Zuluaga, H. Rolf Jager, Parashkev Nachev, Sebastien Ourselin, M. Jorge Cardoso

Vascular graphs can embed a number of high-level features, from morphological parameters, to functional biomarkers, and represent an invaluable tool for longitudinal and cross-sectional clinical inference.

Graph Matching

PIMMS: Permutation Invariant Multi-Modal Segmentation

no code implementations17 Jul 2018 Thomas Varsavsky, Zach Eaton-Rosen, Carole H. Sudre, Parashkev Nachev, M. Jorge Cardoso

In a research context, image acquisition will often involve a pre-defined static protocol and the data will be of high quality.

Segmentation

VTrails: Inferring Vessels with Geodesic Connectivity Trees

no code implementations8 Jun 2018 Stefano Moriconi, Maria A. Zuluaga, H. Rolf Jäger, Parashkev Nachev, Sébastien Ourselin, M. Jorge Cardoso

The analysis of vessel morphology and connectivity has an impact on a number of cardiovascular and neurovascular applications by providing patient-specific high-level quantitative features such as spatial location, direction and scale.

NiftyNet: a deep-learning platform for medical imaging

10 code implementations11 Sep 2017 Eli Gibson, Wenqi Li, Carole Sudre, Lucas Fidon, Dzhoshkun I. Shakir, Guotai Wang, Zach Eaton-Rosen, Robert Gray, Tom Doel, Yipeng Hu, Tom Whyntie, Parashkev Nachev, Marc Modat, Dean C. Barratt, Sébastien Ourselin, M. Jorge Cardoso, Tom Vercauteren

NiftyNet provides a modular deep-learning pipeline for a range of medical imaging applications including segmentation, regression, image generation and representation learning applications.

Data Augmentation Image Generation +4

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